▶ 학력

- 2002 - 2008 : Univ. of Michigan-Ann Arbor, 화학과 이학박사

- 1995 - 1997 : 국립부산대학교 화학과 석사

- 1991 - 1995 : 국립창원대학교 화학과 학사

▶ 경력

- 2010 ~ 현재 : 한국교통대학교 식품생명학부 생명공학전공 교수

- 2017 ~ 2018 : Scripps Institute of Oceanography-UCSD, 방문교수

- 2015 ~ 2017 : 국제학술지 Applied Biological Chemistry(ABCh),  편집위원

- 2013 ~ 2015 : KOICA 글로벌 연구 사업(지역바이오소재 부가가치 창출과정) 교육강사

- 2008 ~ 2010 : Massachusetts Institute of Technology (MIT), 박사후 연구원

- 1997 ~ 1999 : 한국신발피혁연구소 (KIFLT), 연구원

▶ 연구 업적

[학술논문]

- 43. Chonthicha Kongkwamcharoen, Arunporn Itharat, Wichan Ketjinda, Hyang-Yeol Lee, Gi-Seong Moon, and Neal M. Davies, ‘Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract’, RESEARCH IN PHARMACEUTICAL SCIENCES, 18(3), 244-261, 2023.

- 42. Hyang-Yeol Lee and Jun-Sub Kim, ‘Cherry fruit anthocyanins cyanidin-3-O-glucoside and cyanidin-3-O-rutinoside protect against blue light-induced cytotoxicity in HaCaT cells’, Applied Biological Chemistry, 66, 3, 2023.

- 41. Ji-Hae Joo, Min-Hui Han, Ja-I Kim, Jong-Eun Kim, Kyung-Hwan Jung, Han Sun Oh, Young Soo Chung, Hyun Jin An, Jae Duk lee, Gi-Seong Moon, and Hyang-Yeol Lee, ‘Antimicrobial activity of Smilax china L. root extracts against the acne-causing bacterium, Cutibacterium acnes, and its active compounds’, Molecules, 27, 8331, 2022.

- 40. Kalyarut Phumlek, Arunporn Itharat, Padcha Pongcharoen, Panlop Chakkavittumrong, Hyang-Yeol Lee, Gi-Seong Moon, Min-Hui Han, Summalee Panthong, Wichan Ketjinda, and Neal M. Davies, ‘Garcinia mangostana hydrogel patch: bactericidal activity and clinical safety for acne vulgaris treatment’, RESEARCH IN PHARMACEUTICAL SCIENCES, 17(5), 457-467, 2022.

- 39. Ji Yeon Lee, YongGyeong Kim, Ja-I Kim, Hyang-Yeol Lee, Gi-Seong Moon, and Chang-Ho Kang, ‘Improvements in Human Keratinocytes and Antimicrobial Effect Mediated by Cell-Free Supernatants Derived from Probiotics’, Fermentation, 8, 332, 2022.

- 38. Kim et al, ‘In vitro and in vivo anti-tumor efficacy of krill oil against bladder cancer involvement of tumor-associated angiogenic vascularture’, Food research international, 156, 111144, 2022.

- 37. MooSung Kim, Hyun Young Shin, Hyun-Gyeong Kim, Ju Sung Kang, Kyung-Hwan Jung, Kwang-Won Yu, Gi-Seong Moon, and Hyang-Yeol Lee, ‘Anti-inflammatory activity and toxicity of the compound K produced by bioconversion’, J. of the Korean Applied Science and Technology, 38(6), 1466-1475, 2021.

- 36. MooSung Kim, Ja-I Kim, Kyung-Hwan Jung, Kwang-Won Yu, Gi-Seong Moon, and Hyang-Yeol Lee, ‘Biosynthesis of Compound K, a biologically active saponin of ginseng (Panax ginseng) by bioconversion’, J. of the Korean Applied Science and Technology, 38(5), 1335-1344, 2021.

- 35. Hyang-Yeol Lee, Hong-Jong Jin, Seung Hye An, Hye Won Lee, and Kyung-Hwan Jung, ‘Confirmation of Enzymatic Synthesis of 1,2-Octanediol Galactoside using Mass Spectrometry and NMR Spectroscopy’, J. of the Korean Applied Science and Technology, 38(3), 824-831, 2021.

- 34. Hong-Joo Byun, Kyung-Hwan Jung, Giseong Moon, Sung-Kwon Moon and Hyang-Yeol Lee, ‘A Facial and Efficient Method for the Synthesis of Crystalline Tetrahydro-b-Carbolines via the Pictet-Spengler Reaction in Water’, Scientific Reports, 10, 1057, 2020.

- 33. Hong-Ju Byeon, Min-Hui Han, Gi-Seong Moon, Kyung-Hwan Jung, Hyang-Yeol Lee, ‘Synthesis and Structural Characterization of b-Caboline Compounds’, J. of the Korean Oil Chemists’ Soc., 36(2), 676-684, 2019.

- 32. Hyang-Yeol Lee, Kyung-Hwan Jung, ‘NMR Spectroscopy and Mass Spectrometry of Benzyl Alcohol Galactoside synthesized using b-Galactosidase’, , J. of the Korean Oil Chemists’ Soc., 36(1), 84-89, 2019.

- 31. Hong-Ju Byeon, Hyang-Yeol Lee, ‘Probiotics and Prebiotics to Replace Antibiotics’, Journal of Biotechnology and Bioindustry, 6, 20-25, 2018.

- 30. Hong-Ju Byeon, Hyang-Yeol Lee, ‘Fusion Anti-Cancer Drugs of Cisplatin Analogue and Fatty Acids for Multi-Targeted Cancer Treatment’, J. of the Korean Oil Chemists’ Soc., 35(4), 1385-1391, 2018.

- 29. Hong-Ju Byeon, Won-Seok Choi, Hyang-Yeol Lee, ‘The Physical Properties of the Cosmetic Hydrogels Affected by Adding Various Celluloses’, J. of the Korean Oil Chemists’ Soc., 35(3), 702-708, 2018.

- 28. Hong-Ju Byeon, Hyang-Yeol Lee, ‘Hydrogel Mask Packs: Facial Skincare Beauty Products’, Journal of Biotechnology and Bioindustry, 4, 115-118, 2016.

- 27. Hong-Ju Byeon, Sang Hyeok Lee, Hyang-Yeol Lee, ‘Cotton Hydrogel Mask Packs Treated with Cellulase’, Journal of Biotechnology and Bioindustry, 4, 19-22, 2016.

- 26. Jun-Sub Kim, Il-Hwan Yu, Ji-Hye Joo, Gyeong Hoe Nam, Kyung-Hwan Jung, Young Soo Chung, Hyang-Yeol Lee, ‘Biological Effects of Vinca minor extract; Tyrosinase Inhibition, Stimulation of ROS generation and Increasement of Cell Migration Activity in Keratinocytes’, J. of the Korean Oil Chemists’ Soc., 33(4), 788-794, 2016.

- 25. Yi-Ok Kim, Hyang-Yeol Lee, Kyung-Hwan Jung, ‘NMR Spectroscopy and Mass Spectrometry of 1,2-Hexanediol Galactoside Synthesized using Escherichia coli b-Galactosidase’, J. of the Korean Oil Chemists’ Soc.,33(2), 286-292, 2016.

- 24. Sang-Min Lee, Ji-Hye Joo, Hyang-Yeol Lee, ‘Preparation of Wood Adhesives from the Rice Powder and pMDIs; Characterizations of their properties’ , J. of the Korean Oil Chemists’ Soc., 32(4), 607-615, 2015.

- 23. Jung Hei, Choi, Eunae Kim, Ung Chan Yoon and Hyang-Yeol Lee, ‘ Synthesis and Characterization of Soluble Silyl End-Capped Arene-Thiophen co-Oligomers’ Bull. Koran Chem. Soc. 36(5) 2015.

- 22. Jun-Sub Kim, Ji-Hae Joo, Jo-Eun Kang, Sun-Dong Jang, Kyung-Hwan Jung, Gi-Seong Moon, Hyang-Yeol Lee, Antioxidant Effects and Spectrophotometry Analysis of Alkaloids from Vinca minor, J. of the Korean Oil Chemists’ Soc., 32(1), 16-22, 2015.

- 21. Jun-Sub Kim, Jo-Eun Kang, Il-Hwan Yu, Kyung-Hwan Jung, Gi-Seong Moon, Hyang-Yeol Lee, Antimicrobial and Immunological activites of Vinca minor Extracts, J. of the Korean Oil Chemists’ Soc., 32(1), 108-115, 2015.

- 20. Kyung-Hwan Jung and Hyang-Yeol Lee, ‘Escherichia coli b-galactosidase-catalyzed synthesis of 2-phenoxyethanol galactoside and its characterization’ Bioprocess Biosyst Eng. 38(2) 365-372, 2015.

- 19. Hyang-Yeol Lee and Kyun-Hwan Jung, ‘ Enzymatic Synthesis of 2-phenoxyethanol Galactoside by Whole Cells of b-Galactosidase-Containing Escherichia coli. J. Microbiol. Biotehcnol. 24(9), 1254-1259, 2014

- 18. Hyang-Yeol Lee, ‘Wood Adhesives Synthesized from the Isocyanate and Environment-Friendly Bio-materials’. Journal of Biotechnology and Bioindustry, 1, 51-55, 2013.

- 17. Sang-Eun Lee, Tae-Min Jo, Hyang-Yeol Lee, Jongsung Lee, Kyung-Hwan Jung, ‘β-Galactosidase-Catalyzed Synthesis of Galactosyl Chlorphenesin and Its Characterization.’ Applied Biochemistry and Biotechnology, 171, 1299-1312, 2013

- 16. Sang-Eun Lee, Hyang-Yeol Lee, and Kyung-Hwan Jung, ‘Production of Chlorphenesin Galactoside by Whole Cells of β-Galactosidase-Containing Escherichia coli.’ Journal of microbiology and biotechnology, 23(6), 826-832, 2013.

- 15. Hea Jung Park, Ung Chan Yoon, Hyang-Yeol Lee, Dae Won Cho, Dae Won Cho and Paterik S. Marianol, ‘Photoaddition reactions of acetylpyridines with silyl ketene acetals: SET vs [2+2]-cycloaddition pathways, Journal of Organic Chemistry, 77, 10304-10313, 2012.

- 14. Yuna Ha, Sang-Min Lee and Hyang-Yeol Lee, ‘Synthesis of Wood Adhesive Derived from the Milk Protein and the Blocked Isocyanate’, J. of the Korean Oil Chemists’Soc., 30(3), 551-559, 2010.

- 13. Soo, Lee and  Hyang-Yeol Lee,  Cytochrome P-450 2A6 Inhibitor Based on the Indole Moiety, J. of the Korean Oil Chemists’ Soc., 29(3), 2010.

- 12. Hyang-Yeol Lee, ‘Analytical Characterization of Aza-Indole Alkaloids in the Biosynthesis of Catharanthus roseus, J. of the Korean Oil Chemists’ Soc., 29(2), 248-256, 2010.0

- 11. Soo, Lee and Hyang-Yeol Lee, ‘Studies of vindoline metabolism in Catharanthus roseus cell cultures using deuterium-labeled tabersonine,’ J. of the Korean Oil Chemists’ Soc., 29(1), 71-80, 2010.

- 10. Sangwon Lee, Hyang-Yeol Lee, Soo Lee, ‘Effect of propyl gallate on the properties of regenerated cellulose fiber spun from NMMO dope system’ J. of the Korean Oil Chemists’ Soc., 27 (4), 508-514,  2010.

- 9. Hyang-Yeol Lee, Nancy Yerkes, and Sarah E. O’Connor, ‘Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis’, Chemistry and Biology, 16 (12), 1225-1229, 2009.

- 8. Cho, Dae Won, Lee, Hyang-Yeol, Oh, Sun Wha, Choi, Jung Hei, Park, Hea Jung, Mariano, Patrick S., Yoon, Ung Chan. ‘Photoaddition Reactions of 1,2-Diketones with Silyl Ketene Acetals. Formation of ？-Hydroxy-？-ketoesters’. Journal of Organic Chemistry, 73(12), 4539-4547, 2008.

- 7. Lindsey M. Gottler, Hyang-Yeol Lee, Charles E. Shelburne, Ayyalusamy Rammamoorthy and E. Neil G. Marsh, ‘Using fluorous amino acids to enhance the biological stability of an antimicrobial peptide’, ChemBioChem, 9(3), 370-373, 2008.

- 6. Hyang-Yeol Lee, Jeffery W. Kampf, Kyo-SungParkandE.NeilG.Marsh,  ‘Covalent Metal-Peptide Framework Compounds that Extend in One and Two Dimensions.’ Crystal Growth & Design, 8(1), 296-303, 2008.

- 5. Miri Yoon, Anastasia Kalli, Hyang-Yeol Lee, Kristina Hakkansson and E. Neil G. Marsh, ‘Intrinsic Deuterium Kinetic Isotope Effects in Glutamate Mutase Measured by an Intra-molecular Competition Experiment.’ Angewante Chemie International Edition, 46(44), 8455-8459, 2007.

 - 4. Hyang-Yeol Lee, Miri Yoon and E. Neil G. Marsh, ‘Synthesis of mono- and di-deuterated (2S, 3S)-3-methylaspartic acids to facilitate measurement of intrinsic kinetic isotope effects in enzymes.’ Tetrahedron, 63, 4663-4668, 2007.

- 3. Hyang-Yeol Lee; Kyung-Hoon Lee; Hashim M Al-Hashimi; E Neil G Marsh, ‘Modulating Protein Structure with Fluorous Amino Acids: Increased Stability and Native-like Structure Conferred on a 4-Helix Bundle Protein by Hexafluoroleucine.’ Journal of the American Chemical Society, 128(1), 337-43, 2006.

- 2. Kyung-Hoon Lee, Hyang-Yeol Lee, Morris M. Slutsky, James T. Anderson, and E. Neil G. Marsh, 'Fluorous effect in Proteins: De Novo Design and Characterization of a Four-？-helix Bundle Protein containing Hexafluoroleucine.' Biochemistry, Vol. 43, 16277-16284, 2004.

- 1. Young Kook Kim, Yun-Ho Lee, Hyang-Yeol Lee, Mi Kyung Kim, Geun Sig Cha, and Kyo Han Ahn, 'Molecular Recognition of Anions through Hydrogen Bonding Stabilization of Anion-Ionophore Adducts: A Novel Trifluoroacetophenone-Based Binding Motif.' Organic. Letters, Vol. 5, No. 21, 4003-4006, 2003.

[연구과제]

- 4. 연구과제명: 약용식물인 망개덩굴로부터 생리활성물질 연구, 연구비지원기관: 연구재단, 과제번호: 2017R1D1A1B03036334

- 3. 연구과제명: 피부개선효과를 지닌 빈카마이너추출물을 사용한 마스크시트팩 제품 개발 및 사업화, 연구비지원기관: 한국산업기술진흥원, 과제번호: 201401740001.

- 2. 연구과제명: 천연물계 목재접착제 제조 및 물성평가, 연구비지원기관: 국립산림과학원, 과제번호: 2013000400001.

- 1. 연구과제명: 비폼알데하이드계 목재접착제 합성 및 분석, 연구비지원기관: 국립산림과학원, 과제번호: 03-2012-0015.

[특허]

- 7. ‘반응촉진제로써 타르타르산과 용매로써 물을 사용한 결정성 테트라하이드로-베타-카볼린의 제조방법(특허출원 진행중), 출원인; 이향렬 정경환, 문기성, 변홍주.

- 6. (특허출원) ‘천연섬유가 도입된 기능성 하이드로겔 팩 및 이의 제조방법’ (출원번호 10-2016-0031808, 출원인: 이향렬, 정경환, 문기성, 김준섭, 주지혜, 이상혁)

- 5. (특허출원) ‘멜라닌 생합성 억제효과가 있는 빈카마이너 추출물을 포함하는 미백용 조성물’ (출원번호 10-2015-0084298, 출원인; 오한선, 정영수, 박예경, 최수정, 이향렬, 정경환, 문기성, 김준섭)

- 4. (특허등록) 재조합 대장균을 이용한 페녹시에탄올 갈락토사이드의 제조방법 및 이에 의해 제조되는 페녹시에탄올 갈락토사이드’ (등록번호 10-1652368-00-00, 출원인: 정경환, 이향렬, 연주혜)

- 3. (상표등록출원)’ (출원번호 40-2014-0010338, 출원인: 이향렬, 정경환, 문기성, 김준섭)

- 2. (특허출원) ‘페리윙클 추출물을 이용한 두피환경개선 조성물, 이를 이용한 두피환경개선 샴푸 및 두피용 화장품.’ (출원번호 10-2014-0017304, 출원인: 이향렬, 정경환, 문기성, 김준섭)

- 1. (특허등록) ‘대장균의 b-갈락토시다제를 이용한 클로페네신 갈락토사이드의 제조 방법.’ (출원번호 10-2013-0002237, 특허번호 제 10-1461170 호. 출원인: 이상은, 조태민, 이향렬, 문성권, 정경환)